Following are cases Which will help you solving this error.
1) This typically happens when you have an attribute of targetFramework="4.0" in the web.config but the App Pool is set to run ASP.NET 2.0. The targetFramework attribute is entirely unrecognized by ASP.NET 2.0 - so changing it to 2.0 won't have the desired effect.
and you have to switched AppPool to 4.0.
You could also remove the attribute entirely, however if your site was coded with the 4.0 Framework, then I'm sure something else will cause an error as well.
2) some time this Error due to registering the framework with IIS is what worked for me:
just run this command on CMD command Prompt . with proper directory according to your PC settings.
C:\WINDOWS\Microsoft.NET\Framework\v4.0.30319>aspnet_regiis -i.
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